This research aims to examine access to medical treatment during the COVID-19 pandemic for people living with disabilities. During the COVID-19 pandemic, the practical and ethical problems of allocating limited medical resources such as intensive care unit beds and ventilators became critical. Although different countries have proposed different guidelines to manage this emergency, these proposed criteria do not sufficiently consider people living with disabilities. People living with disabilities are therefore at a higher risk of exclusion from medical treatments as physicians (...) tend to assume they have poor quality of life, whereas access to medical treatment should be based on several parameters, including clinical data and prognosis. However, the COVID-19 pandemic shifts the medical paradigm from person-centred medicine to community-centred medicine, challenging the main ethical theories. We reviewed the main guidelines and recommendations for resources allocation and examined their position toward persons with disabilities. Based on our findings, we propose criteria for not discriminating against people with disabilities in allocating resources. The shift from person-centred to community-centred medicine offers opportunities but also risks sacrificing the most vulnerable people. The principle of reasonable accommodation must always be considered to guarantee the rights of persons with disabilities. (shrink)

The distinction between analytic and synthetic propositions, and with that the distinction between a priori and a posteriori truth, is being abandoned in much of analytic philosophy and the philosophy of most of the sciences. These distinctions should also be abandoned in the philosophy of mathematics. In particular, we must recognize the strong empirical component in our mathematical knowledge. The traditional distinction between logic and mathematics, on the one hand, and the natural sciences, on the other, should be dropped. Abstract (...) mathematical objects, like transcendental numbers or Hilbert spaces, are theoretical entities on a par with electromagnetic fields or quarks. Mathematical theories are not primarily logical deductions from axioms obtained by reflection on concepts but, rather, are constructions chosen to solve some collection of problems while fitting smoothly into the other theoretical commitments of the mathematician who formulates them. In other words, a mathematical theory is a scientific theory like any other, no more certain but also no more devoid of content. (shrink)

A view of the sources of mathematical knowledge is sketched which emphasizes the close connections between mathematical and empirical knowledge. A platonistic interpretation of mathematical discourse is adopted throughout. Two skeptical views are discussed and rejected. One of these, due to Maturana, is supposed to be based on biological considerations. The other, due to Dummett, is derived from a Wittgensteinian position in the philosophy of language. The paper ends with an elaboration of Gödel's analogy between the mathematician and the physicist.

There is widespread agreement in neuroscience and psychology that the visual system identifies objects and faces based on a pattern of activation over many neurons, each neuron being involved in representing many different categories. The hypothesis that the visual system includes finely tuned neurons for specific objects or faces for the sake of identification, so‐called “grandmother cells”, is widely rejected. Here it is argued that the rejection of grandmother cells is premature. Grandmother cells constitute a hypothesis of how familiar visual (...) categories are identified, but the primary evidence against this hypothesis comes from studies that have failed to observe neurons that selectively respond to unfamiliar stimuli. These findings are reviewed and it is shown that they are irrelevant. Neuroscientists need to better understand existing models of face and object identification that include grandmother cells and then compare the selectivity of these units with single neurons responding to stimuli that can be identified. (shrink)

La vie de Nicolas d'Autrecourt (1298-1369) connait un tournant decisif en 1346. Il est en effet contraint d'abjurer certaines de ses theses et de renoncer a tout droit a l'enseignement. Celui qui fut vers 1330-1340 l'une des principales figures de la faculte des Arts, aux cotes de Buridan, doit mettre un terme a une oeuvre philosophique deja riche de promesses. On propose ici la premiere traduction francaise de la Correspondance que Nicolas d'Autrecourt a entretenue avec le franciscain Bernard (...) d'Arezzon et le maitre es arts Gilles du Foin. Il esquisse la certains des themes importants de son epistemologie, exposant notamment les criteres de la connaissance evidente et developpant une theorie des inferences originale. On trouvera egalement une traduction des theses que Nicolas d'Autrecourt dut abjurer. On pourra ainsi se faire une idee de certaines de ses preoccupations intellectuelles qui n'apparaissent pas dans la correspondance et essayer de comprendre pourquoi la carriere d'un intellectuel prometteur fut ainsi brisee. (shrink)

01. Athènes, Attique, Mégaride (Despina Chatzivasiliou) Généralités 01.01 – Ces dernières années, nombreuses sont les études qui parcourent l’histoire d’Athènes et de l’Attique, proposent de nouvelles interprétations des trouvailles anciennes et remanient les théories existantes dans la bibliographie. Une attention particulière est portée à la géographie et à l’organisation topographique des espaces, et le besoin d’un éclaircissement dans la bibliographie en croissance constante est évident....

The growing popularization of stakeholder theory among management scholars has offered a useful framework for understanding the multiple and interdependent roles of government and business in an increasingly challenging political and regulatory environment. Despite this trend, attention to the role and responsibility of government to protect citizen rights has been limited. To the two traditional stakeholder theory views of government where the focal organization remains the firm, we propose to add two views by pivoting the government’s place and making it (...) the focal organization. We thus describe governments as serving four roles in the business–government–society nexus. For each role, we analyze typical governmental activities/behaviors, relationships with firms’ stakeholders, as well as the challenges and limits to these roles. We also focus on the central notion of salience amplification, as a means of checks and balances across stakeholders in order to safeguard citizen rights and reveal the greater good. (shrink)

Because rate of force development is an emerging outcome measure for the assessment of neuromuscular function in unfatigued conditions, and it represents a valid alternative/complement to the classical evaluation of pure maximal strength, this scoping review aimed to map the available evidence regarding RFD as an indicator of neuromuscular fatigue. Thus, following a general overview of the main studies published on this topic, we arbitrarily compared the amount of neuromuscular fatigue between the “gold standard” measure and peak, early and late (...) RFD. Seventy full-text articles were included in the review. The most-common fatiguing exercises were resistance exercises, endurance exercises/locomotor activities, isokinetic contractions, and simulated/real sport situations. The most widely tested tasks were knee extension and plantar flexion. The reason for evaluating RFD was lacking in 36% of the studies. On average, the amount of fatigue for MVF was comparable to late RFD but lower compared to both peak RFD and early RFD. Even if the rationale for evaluating RFD in the fatigued state was often lacking and the specificity between test task and fatiguing exercise characteristics was not always respected in the included studies, RFD seems to be a valid indicator of neuromuscular fatigue. Based on our arbitrary analyses, peak RFD and early phase RFD appear even to be more sensitive to quantify neuromuscular fatigue than MVF and late phase RFD. (shrink)

The purpose of this paper is to show how the paradox of knowability loses its paradoxical character when we correctly interpret one of its premises. It is then shown how this new interpretation can be used to logically define analytical and synthetic truths. In this way, the paradox of knowability is traced back to the harmless affirmation that, in order to know every proposition with certainty, there must be no propositions whose truth is synthetic.

The impact of Darwin's work in biology is widely known; we present here a less known aspect which is that of applying Darwin's ideas in physics, and how this may relate with the transition from pre-life to life. Darwin's work on the origin of species was a breakthrough not only because of its explanation of how different species came to exist but also because the extinction of a species is caused not only by the charactenstics of the species, but in (...) large degree by the charactenstics of the environment. In contrast, in Newton's approach to physics, the environment was seen as neutral and inert. The goal of this article is to portray how quantum Darwinism helps to clarify the transition from Physics to pre-life. (shrink)

Obsessive–compulsive disorder is a debilitating mental health disorder that can easily become a treatment-resistant condition. Although effective therapies exist, only about half of the patients seem to benefit from them when we consider treatment refusal, dropout rates, and residual symptoms. Thus, providing effective augmentation to standard therapies could improve existing treatments. Group compassion-focused interventions have shown promise for reducing depression, anxiety, and avoidance related to various clinical problems, but this approach has never been evaluated for OCD individuals. However, cultivating compassion (...) for self and others seems crucial for OCD patients, given the accumulating research suggesting that fear of guilt, along with isolation and self-criticism, can strongly contribute to the development and maintenance of OCD. The primary aim of this pilot study was to evaluate the acceptability, tolerability, and effectiveness of an 8-week group compassion-focused intervention for reducing OCD symptoms, depression, fear of guilt and self-criticism, and increasing common humanity and compassionate self-reassuring skills in treatment-resistant OCD patients. Using a multiple baseline experimental design, the intervention was evaluated in a sample of OCD patients who had completed at least 6 months of CBT treatment for OCD, but who continued to suffer from significant symptoms. Participants were randomized to different baseline assessment lengths; they then received 8 weekly, 120-min group sessions of compassion-focused therapy for OCD, and then were tested again at post-treatment and at 1 month follow up. Despite the adverse external circumstances, by the end of treatment, all participants demonstrated reliable decreases in OCD symptoms, and these improvements were maintained at 4-week follow-up for seven of eight participants. The intervention was also associated with improvements in fear of guilt, self-criticism, and self-reassurance, but less consistent improvements in depression and common humanity. Participants reported high levels of acceptability of and satisfaction with the intervention. Results suggest that the intervention may be beneficial as either a stand-alone treatment or as an augmentation to other treatments. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Nul n'est plus fuyant que le mauvais goût. Qu'il soit relatif, ancré dans son temps, frontière sociale ou revendiqué tel une profession de foi artistique. Dans ce Dictionnaire amoureux intime et partial, Nicolas d'Estienne d'Orves vous invite dans son grenier braillard et cocasse. 'Le mauvais goût échappe à toute définition, famille ou clan. Tout comme le bon goût, il est relatif, circonstanciel, ancré dans son temps. Il peut également être une frontière sociale, un racisme de classe. En ce cas, (...) le mauvais goût c'est celui de l'autre, celui qu'on n'a pas et qu'on se défend d'avoir au risque de trahir les siens. Enfin il y a le mauvais goût patenté, revendiqué, qui n'est pas une attitude, une mode, mais une profession de foi artistique, un manifeste esthétique. C'est -sans doute- ce qu'on pourrait appeler le kitsch. C'est-à-dire un style en soi, des formes volontaires, pensées, destinées à déranger la norme. Ce livre sera donc, par essence, partial. Avec le mauvais goût, j'entre dans une zone marécageuse. Est-il possible de faire un livre plus intime, plus narcissique, puisqu'il explore la part d'ombre de ma propre sensibilité? Petit enfant sous Giscard, adolescent sous Mitterrand, j'ai pris racine dans des époques aux esthétiques très contrastées qui seront forcément présentes dans ces pages. Souvenirs intimes, émissions de télévision, films, livres, plats, commerces, personnages imaginaires ou pas, attitudes de tous poils, mon mauvais goût est une auberge qui n'a rien d'espagnole mais tout d'un grenier. Un grenier braillard et cocasse, que j'ai moi-même tenté de ranger pour les besoins de la cause. Le mauvais goût ne se partage pas, en ce qu'il est une exploration de nos propres frontières esthétiques, la ligne de crête entre ce que l'on goûte et ce que l'on recrache. Bienvenue dans mon train fantôme!'"--Page 4 of cover. (shrink)